As to the causation, of the feeling of meaningless, one may say, albeit in an oversimplifying way, that people have enough to live by but nothing to live for; they have the means but no meaning.
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About Viktor E. Frankl
Viktor E. Frankl was a 20th-century Austrian neurologist. Viktor Emil Frankl was an Austrian neurologist, psychiatrist, philosopher, and Holocaust survivor, who founded logotherapy, a school of psychotherapy that describes a search for a life's meaning as the central human motivational force. Logotherapy is part of existential and humanistic psychology theories. Read more on Wikipedia →